Salinomycin induces calpain and cytochrome c-mediated neuronal cell death
نویسندگان
چکیده
منابع مشابه
Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia.
Collapsin response mediator proteins (CRMPs) mediate growth cone collapse during development, but their roles in adult brains are not clear. Here we report the findings that the full-length CRMP-3 (p63) is a direct target of calpain that cleaves CRMP-3 at the N terminus (+76 amino acid). Interestingly, activated calpain in response to excitotoxicity in vitro and cerebral ischemia in vivo also c...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2011
ISSN: 2041-4889
DOI: 10.1038/cddis.2011.46